Moniliformin Analysis Essay

1. Bernstein CN, Wajda A, Svenson LW, MacKenzie A, Koehoorn M, et al. (2006) The epidemiology of inflammatory bowel disease in Canada: a population-based study. Am J Gastroenterol101: 1559–1568 [PubMed]

2. Salim SY, Soderholm JD (2011) Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis17: 362–381 [PubMed]

3. Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology140: 1756–1767 [PMC free article][PubMed]

4. Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, et al. (2011) Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14 macrophages. Gastroenterology141: 2026–2038 [PubMed]

5. Sarra M, Monteleone I, Stolfi C, Fantini MC, Sileri P, et al. (2010) Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm Bowel Dis16: 1332–1339 [PubMed]

6. Indar AA, Young-Fadok TM, Heppell J, Efron JE (2009) Effect of perioperative immunosuppressive medication on early outcome in Crohn's disease patients. World J Surg33: 1049–1052 [PubMed]

7. Ruixue Luo LL, Chaoqun Xue, Jianyun Jiang (2012) Understanding Infliximab in Crohn's Disease: The Long-Term Outcomes. Journal of Sichuan of Traditional Medicine.

8. Wood JE, Schneider H, Rudd CE (2006) TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1. J Biol Chem281: 32385–32394 [PubMed]

9. Luo Q, Gu Y, Zheng W, Wu X, Gong F, et al. (2011) Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. Toxicol Appl Pharmacol251: 130–136 [PubMed]

10. Bauer B, Baier G (2002) Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration. Mol Immunol38: 1087–1099 [PubMed]

11. Kim EH, Suresh M (2013) Role of PI3K/Akt signaling in memory CD8 T cell differentiation. Front Immunol4: 20. [PMC free article][PubMed]

12. Chen ML, Tsai TC, Lin YY, Tsai YM, Wang LK, et al. (2011) Antipsychotic drugs suppress the AKT/NF-kappaB pathway and regulate the differentiation of T-cell subsets. Immunol Lett140: 81–91 [PubMed]

13. Patel RK, Mohan C (2005) PI3K/AKT signaling and systemic autoimmunity. Immunol Res31: 47–55 [PubMed]

14. Gupta S, Krasnoff SB, Underwood NL, Renwick JA, Roberts DW (1991) Isolation of beauvericin as an insect toxin from Fusarium semitectum and Fusarium moniliforme var. subglutinans. Mycopathologia115: 185–189 [PubMed]

15. Ovchinnikov YA, Ivanov VT, Mikhaleva II (1971) The synthesis and some properties of beauvericin. Tetrahedron Lett: 159–162. [PubMed]

16. Meca G, Sospedra I, Soriano JM, Ritieni A, Moretti A, et al. (2010) Antibacterial effect of the bioactive compound beauvericin produced by Fusarium proliferatum on solid medium of wheat. Toxicon56: 349–354 [PubMed]

17. Zhan J, Burns AM, Liu MX, Faeth SH, Gunatilaka AA (2007) Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum. J Nat Prod70: 227–232 [PMC free article][PubMed]

18. Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, et al. (2009) Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis15: 341–352 [PMC free article][PubMed]

19. Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, et al. (2002) Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol161: 1903–1915 [PMC free article][PubMed]

20. Appleyard CB, Wallace JL (1995) Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am J Physiol269: G119–125 [PubMed]

21. Guo W, Liu W, Hong S, Liu H, Qian C, et al. (2012) Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis. PLoS One7: e46018. [PMC free article][PubMed]

22. Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, et al. (2011) Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain152: 2605–2615 [PubMed]

23. Besliu AN, Pistol G, Marica CM, Banica LM, Chitonu C, et al. (2009) PI3K/Akt signaling in peripheral T lymphocytes from systemic lupus erythematosus patients. Roum Arch Microbiol Immunol68: 69–79 [PubMed]

24. Mak LH, Vilar R, Woscholski R (2010) Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol3: 157–163 [PMC free article][PubMed]

25. Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, et al. (2010) A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest120: 681–693 [PMC free article][PubMed]

26. Hendrickson BA, Gokhale R, Cho JH (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev15: 79–94 [PMC free article][PubMed]

27. Dothel G, Vasina V, Barbara G, De Ponti F (2013) Animal models of chemically induced intestinal inflammation: Predictivity and ethical issues. Pharmacol Ther. [PubMed]

28. Wang Q, Xu L (2012) Beauvericin, a bioactive compound produced by fungi: a short review. Molecules17: 2367–2377 [PubMed]

29. Wejman J, Bielecki K, Ostrowska J, Baczuk L, Perkowska-Ptasinska A, et al. (2006) Pathological analysis of lesions within intestines resected due to ulcerative colitis. Pol J Pathol57: 113–116 [PubMed]

30. Zheng JJ, Cu XQ, Shi XH, Wang YM, Jia LM, et al. (2007) Colonoscopic and histologic features of colonic Crohn's disease in Chinese patients. J Dig Dis8: 35–41 [PubMed]

31. Kaplan DH, Igyarto BZ, Gaspari AA (2012) Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol12: 114–124 [PMC free article][PubMed]

32. Guri AJ, Mohapatra SK, Horne WT 2nd, Hontecillas R, Bassaganya-Riera J (2010) The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol10: 60. [PMC free article][PubMed]

33. Peng XD, Wu XH, Chen LJ, Wang ZL, Hu XH, et al. (2010) Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J Pharmacol Exp Ther332: 46–56 [PubMed]

34. Kuhl AA, Pawlowski NN, Grollich K, Loddenkemper C, Zeitz M, et al. (2007) Aggravation of intestinal inflammation by depletion/deficiency of gammadelta T cells in different types of IBD animal models. J Leukoc Biol81: 168–175 [PubMed]

35. Ficheux AS, Sibiril Y, Parent-Massin D (2013) Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: An in vitro study. Toxicon71: 1–10 [PubMed]

36. Logrieco A, Moretti A, Castella G, Kostecki M, Golinski P, et al. (1998) Beauvericin production by Fusarium species. Appl Environ Microbiol64: 3084–3088 [PMC free article][PubMed]

37. Sheikh SZ, Plevy SE (2010) The role of the macrophage in sentinel responses in intestinal immunity. Curr Opin Gastroenterol26: 578–582 [PMC free article][PubMed]

38. Sasaki M, Klapproth JM (2012) The role of bacteria in the pathogenesis of ulcerative colitis. J Signal Transduct2012: 704953. [PMC free article][PubMed]

39. Shanahan F, Nally K, O'Sullivan GC (2000) Turning on T-cell death and turning off Crohn's disease. Gastroenterology119: 1166–1168 [PubMed]

40. Moro H, Otero DC, Tanabe Y, David M (2011) T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One6: e24972. [PMC free article][PubMed]

41. Monteleone I, Vavassori P, Biancone L, Monteleone G, Pallone F (2002) Immunoregulation in the gut: success and failures in human disease. Gut50 Suppl 3III60–64 [PMC free article][PubMed]

42. Neurath MF, Finotto S, Fuss I, Boirivant M, Galle PR, et al. (2001) Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol22: 21–26 [PubMed]

43. Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, et al. (2012) Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J Autoimmun38: 59–69 [PMC free article][PubMed]

44. Hausmann M, Leucht K, Ploner C, Kiessling S, Villunger A, et al. (2011) BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells. J Biol Chem286: 26533–26540 [PMC free article][PubMed]

45. Jow GM, Chou CJ, Chen BF, Tsai JH (2004) Beauvericin induces cytotoxic effects in human acute lymphoblastic leukemia cells through cytochrome c release, caspase 3 activation: the causative role of calcium. Cancer Lett216: 165–173 [PubMed]


Aquaculture feed manufacturers and producers increasingly recognize the importance of mycotoxins, which contaminate plant-based meals used in compound aquafeeds, and their potential to negatively impact production. Though data on the worldwide occurrence of legislated mycotoxins e.g., trichothecenes and zearalenone (ZEN) are well documented, relatively little information is available regarding other mycotoxins also produced by Fusarium, notably moniliformin (MON). Given that MON is known to affect the survival, growth, skeletal formation and bone mineralization in terrestrial species, its widespread occurrence on maize and maize by-products typically used in aquaculture makes it relevant to study these parameters in teleost fish. In the present work we have tested the effect of MON exposure on survival, bone development and mineralization using zebrafish (Danio rerio) as a model species and fish derived osteo-chondroprogenitor cell line for in vitro studies. Moniliformin exposure did not decrease bone mineralization in zebrafish larvae or extracellular matrix mineralization in the mineralogenic cell line VSa13. Here, the minimal in vitro cytotoxicity concentration was found to be 1000 µg L−1 MON. Incidence of deformities was also not altered by MON at the concentration tested (450 µg L−1) although larval growth was affected, as shown by a decrease in the standard length of exposed specimens at 20 days post fertilization. Survival decreased significantly in larvae exposed to MON concentrations higher than 900 μg L−1. Influence of MON on survival and growth might be relevant for aquaculture industry. As MON is a water-soluble mycotoxin, its leaching from feed is highly probable, so MON assimilation into the surrounding aqueous environment should also be considered. Tested levels in fish larvae are within the reported occurrence levels of MON in commercial feed and plant meals. View Full-Text

Keywords: zebrafish; emerging mycotoxins; Fusarium sp.; cytotoxicity; bone mineralizationzebrafish; emerging mycotoxins; Fusarium sp.; cytotoxicity; bone mineralization

►▼ Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share & Cite This Article

0 Replies to “Moniliformin Analysis Essay”

Lascia un Commento

L'indirizzo email non verrà pubblicato. I campi obbligatori sono contrassegnati *